Neomycin as secondary prophylaxis for irinotecan-induced diarrhea
نویسندگان
چکیده
منابع مشابه
Modulation of irinotecan-induced diarrhea by cotreatment with neomycin in cancer patients.
This study was designed to evaluate irinotecan (CPT-11) disposition and pharmacodynamics in the presence and absence of the broad-spectrum antibiotic neomycin. Seven evaluable cancer patients experiencing diarrhea graded > or =2 after receiving CPT-11 alone (350 mg/m(2) i.v. once every 3 weeks) received the same dose combined with oral neomycin at 1000 mg three times per day (days -2 to 5) in t...
متن کاملSecondary Prophylaxis of Docetaxel Induced Diarrhea with Loperamide: Case Report
Diarrhea is a common adverse event of docetaxel with 20%-40% of incidence and severe diarrhea occurs in 5%-6%. Several treatment guidelines for chemotherapy induced diarrhea (CID) exist, however the prophylaxis for that is not well known. We describe a new prophylactic approach for the CID with loperamide. A 72-yr-old male patient with stage IV non-small-cell lung cancer developed diarrhea repe...
متن کاملDrug prophylaxis for travelers' diarrhea.
Travelers' diarrhea is the most common health impairment in persons visiting developing countries, affecting 20% to >50% of tourists. Although it is usually benign, travelers' diarrhea represents a considerable socioeconomic burden for both the traveler and the host country. The most common enteropathogens are enterotoxigenic and enteroaggregative Escherichia coli. Travelers' compliance with di...
متن کاملIntestinal alkalization as a possible preventive mechanism in irinotecan (CPT-11)-induced diarrhea.
The therapeutic efficacy of irinotecan (CPT-11), a DNA topoisomerase inhibitor, is often limited by the induction of severe late-onset diarrhea. This prodrug and its active metabolite, 7-ethyl-10-hydroxy-camptothecin (SN-38), have a labile alpha-hydroxy-lactone ring that undergoes pH-dependent reversible hydrolysis. At physiological pH and higher, equilibrium favors the less toxic carboxylate f...
متن کاملOral cholera vaccine for traveler's diarrhea prophylaxis.
CLINICAL QUESTION Should the oral cholera vaccine be routinely recommended to prevent traveler's diarrhea (TD)? BOTTOM LINE Randomized controlled trials evaluating oral cholera vaccine for TD did not show a benefit and routine use is not recommended.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2004
ISSN: 0923-7534
DOI: 10.1093/annonc/mdh310